Dataset Information


Mus musculus

ABSTRACT: Gene expression profiling reveals a novel regulatory role for Sox21 in mouse trophoblast stem cell differentiation.

ORGANISM(S): Mus musculus  



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Gene Expression Profiling Reveals a Novel Regulatory Role for Sox21 Protein in Mouse Trophoblast Stem Cell Differentiation.

Moretto Zita Matteo M   Soncin Francesca F   Natale David D   Pizzo Donald D   Parast Mana M  

The Journal of biological chemistry 20151021 50

Appropriate self-renewal and differentiation of trophoblast stem cells (TSCs) are key factors for proper placental development and function and, in turn, for appropriate in utero fetal growth. To identify novel TSC-specific genes, we performed genome-wide expression profiling of TSCs, embryonic stem cells, epiblast stem cells, and mouse embryo fibroblasts, derived from mice of the same genetic background. Our analysis revealed a high expression of Sox21 in TSCs compared with other cell types. So  ...[more]

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