Dataset Information


Homo sapiens

ABSTRACT: Leucegene: AML sequencing (part 5)

ORGANISM(S): Homo sapiens  



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The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.

Lavallée Vincent-Philippe VP   Baccelli Irène I   Krosl Jana J   Wilhelm Brian B   Barabé Frédéric F   Gendron Patrick P   Boucher Geneviève G   Lemieux Sébastien S   Marinier Anne A   Meloche Sylvain S   Hébert Josée J   Sauvageau Guy G  

Nature genetics 20150803 9

Using next-generation sequencing of primary acute myeloid leukemia (AML) specimens, we identified to our knowledge the first unifying genetic network common to the two subgroups of KMT2A (MLL)-rearranged leukemia, namely having MLL fusions or partial tandem duplications. Within this network, we experimentally confirmed upregulation of the gene with the most subtype-specific increase in expression, LOC100289656, and identified cryptic MLL fusions, including a new MLL-ENAH fusion. We also identifi  ...[more]

Publication: 1/3

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