Genomics

Dataset Information

17

Homo sapiens


ABSTRACT: NALP3 inflammasome up-regulation and CASP1 cleavage of the glucocorticoid receptor causes glucocorticoid resistance in leukemia cells [HumanMethylation27]

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA278783 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.

Paugh Steven W SW   Bonten Erik J EJ   Savic Daniel D   Ramsey Laura B LB   Thierfelder William E WE   Gurung Prajwal P   Malireddi R K Subbarao RK   Actis Marcelo M   Mayasundari Anand A   Min Jaeki J   Coss David R DR   Laudermilk Lucas T LT   Panetta John C JC   McCorkle J Robert JR   Fan Yiping Y   Crews Kristine R KR   Stocco Gabriele G   Wilkinson Mark R MR   Ferreira Antonio M AM   Cheng Cheng C   Yang Wenjian W   Karol Seth E SE   Fernandez Christian A CA   Diouf Barthelemy B   Smith Colton C   Hicks J Kevin JK   Zanut Alessandra A   Giordanengo Audrey A   Crona Daniel D   Bianchi Joy J JJ   Holmfeldt Linda L   Mullighan Charles G CG   den Boer Monique L ML   Pieters Rob R   Jeha Sima S   Dunwell Thomas L TL   Latif Farida F   Bhojwani Deepa D   Carroll William L WL   Pui Ching-Hon CH   Myers Richard M RM   Guy R Kiplin RK   Kanneganti Thirumala-Devi TD   Relling Mary V MV   Evans William E WE  

Nature genetics 20150504 6


Glucocorticoids are universally used in the treatment of acute lymphoblastic leukemia (ALL), and resistance to glucocorticoids in leukemia cells confers poor prognosis. To elucidate mechanisms of glucocorticoid resistance, we determined the prednisolone sensitivity of primary leukemia cells from 444 patients newly diagnosed with ALL and found significantly higher expression of CASP1 (encoding caspase 1) and its activator NLRP3 in glucocorticoid-resistant leukemia cells, resulting from significan  ...[more]

Similar Datasets

2015-01-01 | S-EPMC4449308 | BioStudies
| PRJNA277764 | ENA
| PRJNA278781 | ENA
| PRJNA277766 | ENA
| PRJNA278777 | ENA
| PRJNA277765 | ENA
| PRJNA278780 | ENA
| PRJNA278782 | ENA
2015-03-24 | GSE67046 | GEO
2015-03-24 | GSE66705 | GEO