Genomics

Dataset Information

235

Saccharomyces cerevisiae


ABSTRACT: Genome-wide maps of nucleosome positions in purified quiescent S. cerevisiae cells [MNase-Seq]

ORGANISM(S): Saccharomyces cerevisiae  

PROVIDER: PRJNA279129 | ENA |

REPOSITORIES: ENA

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Publications

Global Promoter Targeting of a Conserved Lysine Deacetylase for Transcriptional Shutoff during Quiescence Entry.

McKnight Jeffrey N JN   Boerma Joseph W JW   Breeden Linda L LL   Tsukiyama Toshio T  

Molecular cell 20150820 5


Quiescence is a conserved cell-cycle state characterized by cell-cycle arrest, increased stress resistance, enhanced longevity, and decreased transcriptional, translational, and metabolic output. Although quiescence plays essential roles in cell survival and normal differentiation, the molecular mechanisms leading to this state are not well understood. Here, we determined changes in the transcriptome and chromatin structure of S. cerevisiae upon quiescence entry. Our analyses revealed transcript  ...[more]

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