Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Gene Expression Analysis in NCI-H520 human cancer cells upon deadenylase silencing

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA280404 | ENA |

REPOSITORIES: ENA

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Publications

Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: prognostic value and impact on gene expression.

Maragozidis Panagiotis P   Papanastasi Eirini E   Scutelnic Diana D   Totomi Athina A   Kokkori Ioanna I   Zarogiannis Sotirios G SG   Kerenidi Theodora T   Gourgoulianis Konstantinos I KI   Balatsos Nikolaos A A NA  

Molecular cancer 20151105


Lung cancer is the leading cause of cancer mortality worldwide, mainly due to late diagnosis, poor prognosis and tumor heterogeneity. Thus, the need for biomarkers that will aid classification, treatment and monitoring remains intense and challenging and depends on the better understanding of the tumor pathobiology and underlying mechanisms. The deregulation of gene expression is a hallmark of cancer and a critical parameter is the stability of mRNAs that may lead to increased oncogene and/or de  ...[more]

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