Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Single-cell RNA-seq of murine epidermis

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA280413 | ENA |

REPOSITORIES: ENA

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Publications

Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity.

Joost Simon S   Zeisel Amit A   Jacob Tina T   Sun Xiaoyan X   La Manno Gioele G   Lönnerberg Peter P   Linnarsson Sten S   Kasper Maria M  

Cell systems 20160915 3


The murine epidermis with its hair follicles represents an invaluable model system for tissue regeneration and stem cell research. Here we used single-cell RNA-sequencing to reveal how cellular heterogeneity of murine telogen epidermis is tuned at the transcriptional level. Unbiased clustering of 1,422 single-cell transcriptomes revealed 25 distinct populations of interfollicular and follicular epidermal cells. Our data allowed the reconstruction of gene expression programs during epidermal diff  ...[more]

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