Dataset Information


Homo sapiens

ABSTRACT: Untreated and iron-treated ARPE-19 cell gene expression

ORGANISM(S): Homo sapiens  



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Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-β Signaling in the Retinal Pigment Epithelium.

Li Yafeng Y   Song Delu D   Song Ying Y   Zhao Liangliang L   Wolkow Natalie N   Tobias John W JW   Song Wenchao W   Dunaief Joshua L JL  

The Journal of biological chemistry 20150323 19

Dysregulation of iron homeostasis may be a pathogenic factor in age-related macular degeneration (AMD). Meanwhile, the formation of complement-containing deposits under the retinal pigment epithelial (RPE) cell layer is a pathognomonic feature of AMD. In this study, we investigated the molecular mechanisms by which complement component 3 (C3), a central protein in the complement cascade, is up-regulated by iron in RPE cells. Modulation of TGF-β signaling, involving ERK1/2, SMAD3, and CCAAT/enhan  ...[more]

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