Genomics

Dataset Information

59

Homo sapiens


ABSTRACT: Exploration of PRC2 sigal at gene promoters

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA280510 | ENA |

REPOSITORIES: ENA

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Publications


Polycomb Repressive Complex 2 (PRC2) is an epigenetic regulator induced in many cancers. It is thought to drive tumorigenesis by repressing division, stemness, and/or developmental regulators. Cancers evade immune detection, and diverse immune regulators are perturbed in different tumors. It is unclear how such cell-specific effects are coordinated. Here, we show a profound and cancer-selective role for PRC2 in repressing multiple cytokine pathways. We find that PRC2 represses hundreds of IFNγ s  ...[more]

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