Project description:SOX2 is not expressed in normal human epidermis but its expression is elevated in pre-neoplastic epidermis suggesting that it may have a role in the tumorigenesis process. The goal of this study is to determine the impacts of SOX2 overexpression in regenerated human epidermis. Global gene expression profiling using U133 plus 2.0 arrays were used to deteremine the genes perturbed by overexpression of SOX2.
Project description:Gene expression profiling of immortalized human mesenchymal stem cells with hTERT/E6/E7 transfected MSCs. hTERT may change gene expression in MSCs. Goal was to determine the gene expressions of immortalized MSCs.
Project description:SOX2 signalling is required SCC initiation and maintenance. Ribosome profiling was used to describe the translational landscape of WT and SOX2 overexpressing P4 epidermis.
Project description:Transcriptional profiling of human mesenchymal stem cells comparing normoxic MSCs cells with hypoxic MSCs cells. Hypoxia may inhibit senescence of MSCs during expansion. Goal was to determine the effects of hypoxia on global MSCs gene expression.
Project description:Gene methylation profiling of immortalized human mesenchymal stem cells comparing HPV E6/E7-transfected MSCs cells with human telomerase reverse transcriptase (hTERT)- and HPV E6/E7-transfected MSCs. hTERT may increase gene methylation in MSCs. Goal was to determine the effects of different transfected genes on global gene methylation in MSCs.
Project description:Gene expression profiling of immortalized human mesenchymal stem cells with hTERT/E6/E7 transfected MSCs. hTERT may change gene expression in MSCs. Goal was to determine the gene expressions of immortalized MSCs. One-condition experment, gene expression of 3A6
