Dataset Information


Mus musculus

ABSTRACT: Expression data from mouse brain

ORGANISM(S): Mus musculus  



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Aging without Apolipoprotein D: Molecular and cellular modifications in the hippocampus and cortex.

Sanchez Diego D   Bajo-Grañeras Raquel R   Del Caño-Espinel Manuela M   Garcia-Centeno Rosa R   Garcia-Mateo Nadia N   Pascua-Maestro Raquel R   Ganfornina Maria D MD  

Experimental gerontology 20150411

A detailed knowledge of the mechanisms underlying brain aging is fundamental to understand its functional decline and the baseline upon which brain pathologies superimpose. Endogenous protective mechanisms must contribute to the adaptability and plasticity still present in the healthy aged brain. Apolipoprotein D (ApoD) is one of the few genes with a consistent and evolutionarily conserved up-regulation in the aged brain. ApoD protecting roles upon stress or injury are well known, but a study of  ...[more]

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