Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis [ChIP-seq]

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA282672 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR2002500.fastq.gz Fastqsanger.gz
SRR2002501.fastq.gz Fastqsanger.gz
SRR2002502.fastq.gz Fastqsanger.gz
SRR2002503.fastq.gz Fastqsanger.gz
SRR2002494.fastq.gz Fastqsanger.gz
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Publications

Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis.

Rasmussen Kasper D KD   Jia Guangshuai G   Johansen Jens V JV   Pedersen Marianne T MT   Rapin Nicolas N   Bagger Frederik O FO   Porse Bo T BT   Bernard Olivier A OA   Christensen Jesper J   Helin Kristian K  

Genes & development 20150417 9


DNA methylation is tightly regulated throughout mammalian development, and altered DNA methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in hematological disorders, including acute myeloid leukemia (AML), and has been suggested to protect CG dinucleotide (CpG) islands and promoters from aberrant DNA methylation. In this study, we present a novel Tet2-dependent leukemia mouse model that closely recapitulates gene expression profiles a  ...[more]

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