Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Mouse primary T-ALL microRNA microarray

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA283275 | ENA |

REPOSITORIES: ENA

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Publications

Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression.

Junker Fabian F   Chabloz Antoine A   Koch Ute U   Radtke Freddy F  

Blood 20150515 8


The modulatory function of individual microRNAs (miRNAs) in Notch-driven T-cell acute lymphoblastic leukemias (T-ALLs) has recently been established. Although protumorigenic and tumor-suppressive miRNAs are implicated in disease onset in murine models of Notch-driven T-cell leukemia, whether Dicer1-processed miRNAs are essential for Notch-driven T-ALL is currently unknown. Here we used conditional and inducible genetic loss-of-function approaches to test whether the development and maintenance o  ...[more]

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