Genomics

Dataset Information

235

Mus musculus


ABSTRACT: Parallel single-cell bisulfite- and RNA-sequencing link transcriptional and epigenetic heterogeneity [Bisulfite-Seq]

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA283282 | ENA |

REPOSITORIES: ENA

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Publications


We report scM&T-seq, a method for parallel single-cell genome-wide methylome and transcriptome sequencing that allows for the discovery of associations between transcriptional and epigenetic variation. Profiling of 61 mouse embryonic stem cells confirmed known links between DNA methylation and transcription. Notably, the method revealed previously unrecognized associations between heterogeneously methylated distal regulatory elements and transcription of key pluripotency genes. ...[more]

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