Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: The expression profiles of extracellular matrix-related genes in the presence or absence of EBI3 in the PCR array

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA283295 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

EBI3 Downregulation Contributes to Type I Collagen Overexpression in Scleroderma Skin.

Kudo Hideo H   Wang Zhongzhi Z   Jinnin Masatoshi M   Nakayama Wakana W   Inoue Kuniko K   Honda Noritoshi N   Nakashima Taiji T   Kajihara Ikko I   Makino Katsunari K   Makino Takamitsu T   Fukushima Satoshi S   Ihn Hironobu H  

Journal of immunology (Baltimore, Md. : 1950) 20150909 8


IL-12 family cytokines are implicated in the pathogenesis of various autoimmune diseases, but their role in the regulation of extracellular matrix expression and its contribution to the phenotype of systemic sclerosis (SSc) remain to be elucidated. Among the IL-12 family members, IL-35 decreases type I collagen expression in cultured dermal fibroblasts. IL-35 consists of p35 and EBI3 subunits, and EBI3 alone could downregulate the protein and mRNA expression of type I or type III collagen in the  ...[more]

Similar Datasets

| PRJNA314124 | ENA
| PRJNA148579 | ENA
| GSE78838 | GEO
| PRJNA286288 | ENA
2012-01-01 | E-GEOD-33581 | ArrayExpress
2015-05-08 | E-GEOD-68649 | ArrayExpress
| GSE68649 | GEO
2008-06-16 | E-GEOD-8694 | ArrayExpress
2007-08-08 | GSE8694 | GEO
2010-03-01 | GSE18651 | GEO