Genomics

Dataset Information

235

Homo sapiens


ABSTRACT: The DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer (ChIP-seq)

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA283305 | ENA |

REPOSITORIES: ENA

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Publications

The DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer.

Puto Lorena A LA   Benner Christopher C   Hunter Tony T  

Oncoscience 20150417 4


While carcinoma of the prostate is the second most common cause of cancer death in the US, current methods and markers used to predict prostate cancer (PCa) outcome are inadequate. This study was aimed at understanding the genome-wide binding and regulatory role of the DAXX transcriptional repressor, recently implicated in PCa. ChIP-Seq analysis of genome-wide distribution of DAXX in PC3 cells revealed over 59,000 DAXX binding sites, found at regulatory enhancers and promoters. ChIP-Seq analysis  ...[more]

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