Dataset Information


Homo sapiens

ABSTRACT: human Ino80 chromatin remodeling complex downstream gene

ORGANISM(S): Homo sapiens  



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Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability.

Cao Lingling L   Ding Jian J   Dong Liguo L   Zhao Jiayao J   Su Jiaming J   Wang Lingyao L   Sui Yi Y   Zhao Tong T   Wang Fei F   Jin Jingji J   Cai Yong Y  

PloS one 20150904 9

We previously identified an ATP-dependent human Ino80 (INO80) chromatin remodeling complex which shares a set of core subunits with yeast Ino80 complex. Although research evidence has suggested that INO80 complex functions in gene transcription and genome stability, the precise mechanism remains unclear. Herein, based on gene expression profiles from the INO80 complex-knockdown in HeLa cells, we first demonstrate that INO80 complex negatively regulates the p21Waf1/Cip1 (p21) expression in a p53-  ...[more]

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