Dataset Information


Mus musculus

ABSTRACT: Gene expression profiling of Foxi3 null embryonic back skin epithelium



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Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation.

Shirokova Vera V   Shirokova Vera V   Biggs Leah C LC   Jussila Maria M   Ohyama Takahiro T   Groves Andrew K AK   Mikkola Marja L ML  

Stem cells (Dayton, Ohio) 20160404 7

The hair follicle is an ideal system to study stem cell specification and homeostasis due to its well characterized morphogenesis and stereotypic cycles of stem cell activation upon each hair cycle to produce a new hair shaft. The adult hair follicle stem cell niche consists of two distinct populations, the bulge and the more activation-prone secondary hair germ (HG). Hair follicle stem cells are set aside during early stages of morphogenesis. This process is known to depend on the Sox9 transcri  ...[more]

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