Project description:Clostridium botulinum is a heterogeneous Gram-positive species that comprises four genetically and physiologically distinct groups of bacteria that share the ability to produce botulinum neurotoxin, the most poisonous toxin known to man, and the causative agent of botulism, a severe disease of humans and animals. We report here the complete genome sequence of a representative of Group I (proteolytic) C. botulinum (strain Hall A, ATCC 3502). The genome consists of a chromosome (3,886,916 bp) and a plasmid (16,344 bp) which carry 3,650 and 19 predicted genes, respectively. Consistent with the proteolytic phenotype of this strain, the genome harbours a large number of genes encoding secreted proteases and enzymes involved in uptake and metabolism of amino acids. The genome also reveals a hitherto unknown ability of C. botulinum to degrade chitin. There is a significant lack of recently acquired DNA, indicating a stable genomic content, in strong contrast to the fluid genome of C. difficile, which can form longer-term relationships with its host. Overall, the genome indicates that C. botulinum is adapted to a saprophytic lifestyle both in soil and aquatic environments. This pathogen relies on its toxin to rapidly kill a wide range of prey species, and to gain access to nutrient sources, it releases a large number of extracellular enzymes to soften and destroy rotting or decayed tissues.

2007-05-23 | E-TABM-264 | biostudies-arrayexpress

Clostridium botulinum D str. 1873

Project description:Type D human outbreak strain

| PRJNA33173 | ENA

Clostridium botulinum

Project description:Comparative genomic analysis of C. botulinum isolates from an infant botulism case - Raw sequence reads

| PRJNA610151 | ENA

Clostridium botulinum

Project description:Clostridium botulinum Genome sequencing and assembly of clinical and food isolates from 1995 infant botulism investigation

| PRJNA759433 | ENA

Clostridium botulinum

Project description:Comparative genomic characterization of Clostridium botulinum strains isolated from botulism cases in Japan between 2006 and 2011.

| PRJDB2883 | ENA