Project description:Hispanic/Latino populations possess a complex genetic structure that reflects recent admixture among and potentially ancient substructure within Native American, European, and West African source populations. Here, we quantify genome-wide patterns of SNP and haplotype variation among 100 individuals with ancestry from Ecuador, Colombia, Puerto Rico, and the Dominican Republic genotyped using Illumina technology. To investigate variations of continental ancestry between different Hispanic/Latino groups (using self-reported country-specific identification of individual, both parents, and all four grandparents) and within them from healthy controls represented in the New York Health Project Biorepository. Genotyped on the Illumina 610-Quad, which is identical to HumanHap550-v3 SNPs plus an additional ~60,000 SNPs for CNV, no CNV data is provided or was analyzed.

2010-04-07 | E-GEOD-21248 | biostudies-arrayexpress

NHLBI TOPMed: Genetics of Asthma in Latino Americans (GALA)

Project description:NHLBI TOPMed: Genetics of Asthma in Latino Americans (GALA)

| PRJNA434034 | ENA

NHLBI TOPMed: Genetics of Asthma in Latino Americans (GALA)

Project description:NHLBI TOPMed: Genetics of Asthma in Latino Americans (GALA)

| PRJNA434033 | ENA

Homo sapiens

Project description:Gene-Environment, Admixture and Latino Asthmatics (GALAII) Study SNP Array Data

| PRJNA368778 | ENA

NHLBI TOPMed: Genes-environments and Admixture in Latino Asthmatics (GALA II) Study

Project description:This is a case-only pharmacogenetic study of bronchodilator drug response among racially admixed Latino children with asthma. Each participant had two spirometry measurements using the KoKo PFT System. With the first spirometry test, participant was administered with 4 puffs of HFA Albuterol. The second albuterol measurement was based on age, for participants under 16 years of age, additional 2 puffs were administered and for those over 16 years of age, additional 4 puffs were administered. The overall goal is to identify genetic factors which are predictive of drug response in children with asthma. The principal tools include a questionnaire and biological specimen collection. Participants are 8-21 years old at time of recruitment. Children with asthma have physician-diagnosed asthma, symptoms and medications. Comprehensive phenotypic data for GALAII study participants are available through dbGaP <a href="./study.cgi?study_id=phs001180">phs001180</a>.

| phs000920 | dbGaP

Genes-Environments and Admixture in Latino Asthmatics (GALA II) Study

Project description:A case-control pharmacogenetic study of bronchodilator drug response among racially admixed Latino children with asthma. Each participant had two spirometry measurements using the KoKo PFT System. With the first spirometry test, participant was administered with 4 puffs of HFA Albuterol. The second albuterol measurement was based on age, for participants under 16 years of age, additional 2 puffs were administered and for those over 16 years of age, additional 4 puffs were administered. The overall goal is to identify genetic factors which are predictive of drug response in children with asthma. The principal tools include a questionnaire and biological specimen collection. Participants are 8-21 years old at time of recruitment. Children with asthma have physician-diagnosed asthma, symptoms and medications. The GALAII Study is utilized in the following dbGaP substudies. To view genotypes, analysis, other molecular data, and derived variables collected in these substudies, please click on the following substudies below or in the "Substudies" box located on the right hand side of this top-level study page phs001180 GALAII Study. <ul> <li><a href="./study.cgi?study_id=phs001274">phs001274</a>phs001274 GALAII GWAS</li> </ul>

| phs001180 | dbGaP

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