Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Post-natal age is a critical determinant of the neonatal host response to sepsis

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA286200 | ENA |

REPOSITORIES: ENA

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Publications


Interleukin (IL)-18 is an important effector of innate and adaptive immunity, but its expression must also be tightly regulated because it can potentiate lethal systemic inflammation and death. Healthy and septic human neonates demonstrate elevated serum concentrations of IL-18 compared with adults. Thus, we determined the contribution of IL-18 to lethality and its mechanism in a murine model of neonatal sepsis. We find that IL-18-null neonatal mice are highly protected from polymicrobial sepsis  ...[more]

Publication: 1/2

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