Genomics

Dataset Information

235

Danio rerio


ABSTRACT: MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome [miRNA-seq]

ORGANISM(S): Danio rerio  

PROVIDER: PRJNA286201 | ENA |

REPOSITORIES: ENA

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Publications

MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome.

Chiavacci Elena E   D'Aurizio Romina R   Guzzolino Elena E   Russo Francesco F   Baumgart Mario M   Groth Marco M   Mariani Laura L   D'Onofrio Mara M   Arisi Ivan I   Pellegrini Marco M   Cellerino Alessandro A   Cremisi Federico F   Pitto Letizia L  

Scientific reports 20151214


Holt-Oram Syndrome (HOS) is an autosomal dominant heart-hand syndrome caused by mutations in the TBX5 gene, a transcription factor capable of regulating hundreds of cardiac-specific genes through complex transcriptional networks. Here we show that, in zebrafish, modulation of a single miRNA is sufficient to rescue the morphogenetic defects generated by HOS. The analysis of miRNA-seq profiling revealed a decreased expression of miR-19a in Tbx5-depleted zebrafish embryos compared to the wild type.  ...[more]

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