Genomics

Dataset Information

118

Caenorhabditis elegans


ABSTRACT: Tissue homogeneity requires inhibition of unequal gene silencing during development

ORGANISM(S): Caenorhabditis elegans  

PROVIDER: PRJNA286226 | ENA |

REPOSITORIES: ENA

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Publications

Tissue homogeneity requires inhibition of unequal gene silencing during development.

Le Hai H HH   Looney Monika M   Strauss Benjamin B   Bloodgood Michael M   Jose Antony M AM  

The Journal of Cell Biology 20160725 3


Multicellular organisms can generate and maintain homogenous populations of cells that make up individual tissues. However, cellular processes that can disrupt homogeneity and how organisms overcome such disruption are unknown. We found that ∼100-fold differences in expression from a repetitive DNA transgene can occur between intestinal cells in Caenorhabditis elegans These differences are caused by gene silencing in some cells and are actively suppressed by parental and zygotic factors such as  ...[more]

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