Dataset Information


Mus musculus

ABSTRACT: Gene expression analyses and distribution of H3K4me3 modification during eosinophil development (GMP to EoP to Eosinophil)

ORGANISM(S): Mus musculus  



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Transcription Factor Repertoire of Homeostatic Eosinophilopoiesis.

Bouffi Carine C   Kartashov Andrey V AV   Schollaert Kaila L KL   Chen Xiaoting X   Bacon W Clark WC   Weirauch Matthew T MT   Barski Artem A   Fulkerson Patricia C PC  

Journal of immunology (Baltimore, Md. : 1950) 20150812 6

The production of mature eosinophils (Eos) is a tightly orchestrated process with the aim to sustain normal Eos levels in tissues while also maintaining low numbers of these complex and sensitive cells in the blood. To identify regulators of homeostatic eosinophilopoiesis in mice, we took a global approach to identify genome-wide transcriptome and epigenome changes that occur during homeostasis at critical developmental stages, including Eos-lineage commitment and lineage maturation. Our analyse  ...[more]

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