Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Effect of mutating androgen receptor phosphorylation site Tyr-267

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA286243 | ENA |

REPOSITORIES: ENA

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Publications

Mutation of androgen receptor N-terminal phosphorylation site Tyr-267 leads to inhibition of nuclear translocation and DNA binding.

Karaca Mehmet M   Liu Yuanbo Y   Zhang Zhentao Z   De Silva Dinuka D   Parker Joel S JS   Earp H Shelton HS   Whang Young E YE  

PloS one 20150507 5


Reactivation of androgen receptor (AR) may drive recurrent prostate cancer in castrate patients. Ack1 tyrosine kinase is overexpressed in prostate cancer and promotes castrate resistant xenograft tumor growth and enhances androgen target gene expression and AR recruitment to enhancers. Ack1 phosphorylates AR at Tyr-267 and possibly Tyr-363, both in the N-terminal transactivation domain. In this study, the role of these phosphorylation sites was investigated by characterizing the phosphorylation  ...[more]

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