Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Autoantigen microarrays reveal autoantibodies associated with proliferative nephritis and active disease in pediatric systemic lupus erythematosus

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA286254 | ENA |

REPOSITORIES: ENA

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Publications

Autoantigen microarrays reveal autoantibodies associated with proliferative nephritis and active disease in pediatric systemic lupus erythematosus.

Haddon D James DJ   Diep Vivian K VK   Price Jordan V JV   Limb Cindy C   Utz Paul J PJ   Balboni Imelda I  

Arthritis research & therapy 20150617


Pediatric systemic lupus erythematosus (pSLE) patients often initially present with more active and severe disease than adults, including a higher frequency of lupus nephritis. Specific autoantibodies, including anti-C1q, anti-DNA and anti-alpha-actinin, have been associated with kidney involvement in SLE, and DNA antibodies are capable of initiating early-stage lupus nephritis in severe combined immunodeficiency (SCID) mice. Over 100 different autoantibodies have been described in SLE patients,  ...[more]

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