Dataset Information


Homo sapiens

ABSTRACT: Genome-wide analysis of ADP-ribosylation by ADPr-ChAP reveals its association with chromatin after oxidative stress

ORGANISM(S): Homo sapiens  



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Analysis of Chromatin ADP-Ribosylation at the Genome-wide Level and at Specific Loci by ADPr-ChAP.

Bartolomei Giody G   Leutert Mario M   Manzo Massimiliano M   Baubec Tuncay T   Hottiger Michael O MO  

Molecular cell 20160128 3

Chromatin ADP-ribosylation regulates important cellular processes. However, the exact location and magnitude of chromatin ADP-ribosylation are largely unknown. A robust and versatile method for assessing chromatin ADP-ribosylation is therefore crucial for further understanding its function. Here, we present a chromatin affinity precipitation method based on the high specificity and avidity of two well-characterized ADP-ribose binding domains to map chromatin ADP-ribosylation at the genome-wide s  ...[more]

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