Dataset Information


Saccharomyces cerevisiae

ABSTRACT: localization of Scc2 between wild type and scc4-m35 cells in S-phase

ORGANISM(S): Saccharomyces cerevisiae  



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The SNF2 family ATPase LSH promotes cell-autonomous de novo DNA methylation in somatic cells.

Termanis Ausma A   Torrea Natalia N   Culley Jayne J   Kerr Alastair A   Ramsahoye Bernard B   Stancheva Irina I  

Nucleic acids research 20160513 16

Methylation of DNA at carbon 5 of cytosine is essential for mammalian development and implicated in transcriptional repression of genes and transposons. New patterns of DNA methylation characteristic of lineage-committed cells are established at the exit from pluripotency by de novo DNA methyltransferases enzymes, DNMT3A and DNMT3B, which are regulated by developmental signaling and require access to chromatin-organized DNA. Whether or not the capacity for de novo DNA methylation of developmenta  ...[more]

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