Dataset Information


Mus musculus

ABSTRACT: Expression data from cortical thymic epithelial cells ectopically expressing Aire

ORGANISM(S): Mus musculus  



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Ectopic Aire Expression in the Thymic Cortex Reveals Inherent Properties of Aire as a Tolerogenic Factor within the Medulla.

Nishijima Hitoshi H   Kitano Satsuki S   Miyachi Hitoshi H   Morimoto Junko J   Kawano Hiroshi H   Hirota Fumiko F   Morita Ryoko R   Mouri Yasuhiro Y   Masuda Kiyoshi K   Imoto Issei I   Ikuta Koichi K   Matsumoto Mitsuru M  

Journal of immunology (Baltimore, Md. : 1950) 20151009 10

Cortical thymic epithelial cells (cTECs) and medullary thymic epithelial cells (mTECs) play essential roles in the positive and negative selection of developing thymocytes, respectively. Aire in mTECs plays an essential role in the latter process through expression of broad arrays of tissue-restricted Ags. To determine whether the location of Aire within the medulla is absolutely essential or whether Aire could also function within the cortex for establishment of self-tolerance, we used bacteria  ...[more]

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