Dataset Information


Mus musculus

ABSTRACT: Genome-wide analysis of Estrogen Receptor-mediated response to acute Estradiol treatment in liver (ChIP-seq)

ORGANISM(S): Mus musculus  



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Changes in Gene Expression and Estrogen Receptor Cistrome in Mouse Liver Upon Acute E2 Treatment.

Palierne Gaëlle G   Fabre Aurélie A   Solinhac Romain R   Le Péron Christine C   Avner Stéphane S   Lenfant Françoise F   Fontaine Coralie C   Salbert Gilles G   Flouriot Gilles G   Arnal Jean-François JF   Métivier Raphaël R  

Molecular endocrinology (Baltimore, Md.) 20160510 7

Transcriptional regulation by the estrogen receptor-α (ER) has been investigated mainly in breast cancer cell lines, but estrogens such as 17β-estradiol (E2) exert numerous extrareproductive effects, particularly in the liver, where E2 exhibits both protective metabolic and deleterious thrombotic actions. To analyze the direct and early transcriptional effects of estrogens in the liver, we determined the E2-sensitive transcriptome and ER cistrome in mice after acute administration of E2 or place  ...[more]

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