Dataset Information


Homo sapiens

ABSTRACT: Stimulation of endogenous FGFR2 signalling in estrogen receptor-positive breast cancer cells

ORGANISM(S): Homo sapiens  



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Regulators of genetic risk of breast cancer identified by integrative network analysis.

Castro Mauro A A MA   de Santiago Ines I   Campbell Thomas M TM   Vaughn Courtney C   Hickey Theresa E TE   Ross Edith E   Tilley Wayne D WD   Markowetz Florian F   Ponder Bruce A J BA   Meyer Kerstin B KB  

Nature genetics 20151130 1

Genetic risk for breast cancer is conferred by a combination of multiple variants of small effect. To better understand how risk loci might combine, we examined whether risk-associated genes share regulatory mechanisms. We created a breast cancer gene regulatory network comprising transcription factors and groups of putative target genes (regulons) and asked whether specific regulons are enriched for genes associated with risk loci via expression quantitative trait loci (eQTLs). We identified 36  ...[more]

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