Ontology highlight
ABSTRACT:
PROVIDER: PRJNA290015 | ENA |
REPOSITORIES: ENA
Costello Ita I Nowotschin Sonja S Sun Xin X Mould Arne W AW Hadjantonakis Anna-Katerina AK Bikoff Elizabeth K EK Robertson Elizabeth J EJ
Genes & development 20151001 20
Gene regulatory networks controlling functional activities of spatially and temporally distinct endodermal cell populations in the early mouse embryo remain ill defined. The T-box transcription factor Eomes, acting downstream from Nodal/Smad signals, directly activates the LIM domain homeobox transcription factor Lhx1 in the visceral endoderm. Here we demonstrate Smad4/Eomes-dependent Lhx1 expression in the epiblast marks the entire definitive endoderm lineage, the anterior mesendoderm, and midl ...[more]