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Dataset Information

1K

Mus musculus


ABSTRACT: Molecular function of Lhx1 in early mouse development (BeadChip)

PROVIDER: PRJNA290015 | ENA |

REPOSITORIES: ENA

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Publications

Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development.

Costello Ita I   Nowotschin Sonja S   Sun Xin X   Mould Arne W AW   Hadjantonakis Anna-Katerina AK   Bikoff Elizabeth K EK   Robertson Elizabeth J EJ  

Genes & development 20151001 20


Gene regulatory networks controlling functional activities of spatially and temporally distinct endodermal cell populations in the early mouse embryo remain ill defined. The T-box transcription factor Eomes, acting downstream from Nodal/Smad signals, directly activates the LIM domain homeobox transcription factor Lhx1 in the visceral endoderm. Here we demonstrate Smad4/Eomes-dependent Lhx1 expression in the epiblast marks the entire definitive endoderm lineage, the anterior mesendoderm, and midl  ...[more]

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