Dataset Information


Rattus norvegicus

ABSTRACT: Gene expression of rat cerebellum in a new animal model of hepatic encephalopathy (HE)

ORGANISM(S): Rattus norvegicus  



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Cerebellar neurodegeneration in a new rat model of episodic hepatic encephalopathy.

García-Lezana Teresa T   Oria Marc M   Romero-Giménez Jordi J   Bové Jordi J   Vila Miquel M   Genescà Joan J   Chavarria Laia L   Cordoba Juan J  

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20160720 3

Hepatic encephalopathy has traditionally been considered a reversible disorder. However, recent studies suggested that repeated episodes of hepatic encephalopathy cause persistent impairment leading to neuronal loss. The aims of our study were the development of a new animal model that reproduces the course of episodic hepatic encephalopathy and the identification of neurodegeneration evidences. Rats with portacaval anastomosis underwent simulated episodes of hepatic encephalopathy, triggered by  ...[more]

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