Dietary supplements metagenome
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA291686 | ENA |
REPOSITORIES: ENA
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Project description:Commerical Probioitc Composition
| PRJNA297050 | ENA
Project description:Patients with early stage CLL were recruited into the study and administered a course of omega 3 dietary supplements. Expression profiling of each patient was performed at baseline (before administering the supplement) and after consumption of supplements. Patients were divided into two groups according to the level of NFkB activation at baseline, and then within each of the two groups significant changes in gene expression between baseline and the highest dose of supplements consumed were sought.
2012-12-01 | GSE29678 | GEO
Project description:Analysis of gene expression in skin of rats subjected to electron irradiation and the effect of vitamin A supplements. Keywords: other
2003-03-20 | GSE284 | GEO
Project description:Patients with early stage CLL were recruited into the study and administered a course of omega 3 dietary supplements. Expression profiling of each patient was performed at baseline (before administering the supplement) and after consumption of supplements. Patients were divided into two groups according to the level of NFkB activation at baseline, and then within each of the two groups significant changes in gene expression between baseline and the highest dose of supplements consumed were sought. Patients were divided into two groups based on initial NFkB levels being below (low expressers) or above (high expressers) the median NFkB Activity level (2.14x10^6 NFkB Luminescence units/µg protein). Within each group, paired two class SAM was performed using the maximum supplement dose for each patient versus the baseline.
2012-12-01 | E-GEOD-29678 | biostudies-arrayexpress
Project description:We report the effects of dietary n-3 polyunsaturated fatty acids (PUFAs) on sphingolipid metabolism and airway reactivity in the lung. Mice were fed a n3-PUFA enriched fishoil diet or an isocaloric control coconut oil-enriched diet (CO) for 8 weeks. The n-3 PUFA diet affected pulmonary sphingolipid metabolism, and airway reactivity, independent of inflammation or allergic sensitization. These findings support a role for pulmonary sphingolipid homeostasis in asthma and could have implications for the use of n-3 PUFA dietary supplements in asthma.
2022-08-01 | GSE203418 | GEO
Project description:This trial studies how fiber and fish oil supplements affect the metabolism and activities of colon cells in healthy individuals. Diet is an important risk factor for colorectal cancer, and several dietary components important in colorectal cancer prevention are modified by gut microbial metabolism. Giving fiber and fish oil supplements may inhibit the growth of gut cells and ultimately reduce risk of colorectal cancer.
| 2325667 | ecrin-mdr-crc
Project description:Transcriptional profiling of 3D-retinas differentiated from mouse iPS cells comparing vehicle control with 4-OHT-treated w/o supplements. 4-OHT is an inverse agonist of estrogen-related receptor beta (ERRβ), a rod-enriched transcription factor responsible for maintenance of rod photoreceptor cells and the treatment induces photoreceptor specific cell death in the 3D-retinas. Goal was to understand the mechanism of protective effects of representative ophthalmic supplements for treating the photoreceptor degeneration.
2016-07-05 | GSE83984 | GEO
Project description:Mesenchymal stromal cells (MSCs) are promising candidates for innovative cell therapeutic applications. For clinical scale manufacturing regulatory agencies recommend to replace fetal bovine serum (FBS) commonly used in MSC expansion media as soon as equivalent alternative supplements are available. We already demonstrated that pooled blood group AB human serum (HS) and thrombin-activated platelet releasate plasma (tPRP) support the expansion of multipotent adipose tissue-derived MSCs (ASCs). Slight differences in size, growth pattern and adhesion prompted us to investigate the level of equivalence by compiling the transcriptional profiles of ASCs cultivated in these supplements. A whole genome gene expression analysis was performed and data verified by PCR and protein analyses. Microarray-based screening of 34,039 genes revealed 102 genes differentially expressed in ASCs cultured with FBS compared to HS or tPRP supplements. A significantly higher expression in FBS cultures was found for 90 genes (fold change .2). Only 12 of the 102 genes showed a lower expression in FBS compared to HS or tPRP cultures (fold change .0.5). Differences between cells cultivated in HS and tPRP were hardly evident. Supporting previous observations of reduced adhesion of cells cultivated in the human alternatives we detected a number of adhesion and extracellular matrix associated molecules expressed at lower levels in ASCs cultivated with human supplements. Confirmative assays analysing transcript or protein expression with selected genes supported these results. Likewise a number of mesodermal differentiation associated genes were higher expressed in cells grown in FBS. Quantifying adipogenic and osteogenic differentiation lacked to demonstrate a clear correlation to the supplement due to donor-sepcific variances. Our results emphasize the necessity of comparability studies as they indicate that FBS induces a culture adaptation exceeding that of ex vivo culture in human supplements and thus may contribute to the therapeutic potential.
2010-08-28 | GSE23851 | GEO
Project description:The aim of the present study was to establish the relationship(s) between supplement dose using a novel enriched marine oil preparation, peripheral blood SPM concentrations and cellular responses. We also aimed to assess the kinetics for these responses in order to provide 1) insights into the protective mechanisms activated by omega-3 supplements in humans and 2) novel potential biomarkers for determining the effectiveness of omega-3 supplements at regulating host immune responses.
2019-12-13 | GSE132648 | GEO
Project description:Transcriptional profiling of 3D-retinas differentiated from mouse iPS cells comparing vehicle control with 4-OHT-treated w/o supplements. 4-OHT is an inverse agonist of estrogen-related receptor beta (ERRβ), a rod-enriched transcription factor responsible for maintenance of rod photoreceptor cells and the treatment induces photoreceptor specific cell death in the 3D-retinas. Goal was to understand the mechanism of protective effects of representative ophthalmic supplements for treating the photoreceptor degeneration. 4-OHT w/o supplements-induced gene expression in the 3D-retinas was measured at DD 25 when the photoreceptor cells started to be degenerated. Four-condition experiment, vehicle control- vs. 5 µM 4-OHT- vs. 5 µM 4-OHT with 400 µM vitamin E- vs. 5 µM 4-OHT with 200 nM lutein-treated 3D-retinas. Biological replicates: each sample has 24 3D-retinas and 1replicate.
2016-07-05 | E-GEOD-83984 | biostudies-arrayexpress