Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Identification of a portal vessel-associated fetal liver hematopoietic stem cell niche

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA293804 | ENA |

REPOSITORIES: ENA

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Publications


Whereas the cellular basis of the hematopoietic stem cell (HSC) niche in the bone marrow has been characterized, the nature of the fetal liver niche is not yet elucidated. We show that Nestin(+)NG2(+) pericytes associate with portal vessels, forming a niche promoting HSC expansion. Nestin(+)NG2(+) cells and HSCs scale during development with the fractal branching patterns of portal vessels, tributaries of the umbilical vein. After closure of the umbilical inlet at birth, portal vessels undergo a  ...[more]

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