Dataset Information


Rattus norvegicus

ABSTRACT: Environmentally Induced Epigenetic Transgenerational Inheritance of Altered SRY Genomic Binding During Gonadal Sex Determination

ORGANISM(S): Rattus norvegicus  



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Environmentally induced epigenetic transgenerational inheritance of altered Sertoli cell transcriptome and epigenome: molecular etiology of male infertility.

Guerrero-Bosagna Carlos C   Savenkova Marina M   Haque Md Muksitul MM   Nilsson Eric E   Skinner Michael K MK  

PloS one 20130328 3

Environmental toxicants have been shown to induce the epigenetic transgenerational inheritance of adult onset disease, including testis disease and male infertility. The current study was designed to determine the impact of an altered sperm epigenome on the subsequent development of an adult somatic cell (Sertoli cell) that influences the onset of a specific disease (male infertility). A gestating female rat (F0 generation) was exposed to the agriculture fungicide vinclozolin during gonadal sex  ...[more]

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