Dataset Information


Homo sapiens

ABSTRACT: Cross platform standardization of an experimental pipeline for use in the identification of dysregulated human circulating miRNAs

ORGANISM(S): Homo sapiens  



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Cross Platform Standardisation of an Experimental Pipeline for Use in the Identification of Dysregulated Human Circulating MiRNAs.

Kelly Helena H   Downing Tim T   Tuite Nina L NL   Smith Terry J TJ   Kerin Michael J MJ   Dwyer Róisín M RM   Clancy Eoin E   Barry Thomas T   Reddington Kate K  

PloS one 20150910 9

Micro RNAs (miRNAs) are a class of highly conserved small non-coding RNAs that play an important part in the post-transcriptional regulation of gene expression. A substantial number of miRNAs have been proposed as biomarkers for diseases. While reverse transcriptase Real-time PCR (RT-qPCR) is considered the gold standard for the evaluation and validation of miRNA biomarkers, small RNA sequencing is now routinely being adopted for the identification of dysregulated miRNAs. However, in many cases  ...[more]

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