Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Transcriptome comparison between WT mESC and Tet1,2,3 TKO mESC

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA295969 | ENA |

REPOSITORIES: ENA

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Publications

5-Hydroxymethylcytosine Marks Sites of DNA Damage and Promotes Genome Stability.

Kafer Georgia Rose GR   Li Xuan X   Horii Takuro T   Suetake Isao I   Tajima Shoji S   Hatada Izuho I   Carlton Peter Mark PM  

Cell reports 20160204 6


5-hydroxymethylcytosine (5hmC) is a DNA base created during active DNA demethylation by the recently discovered TET enzymes. 5hmC has essential roles in gene expression and differentiation. Here, we demonstrate that 5hmC also localizes to sites of DNA damage and repair. 5hmC accumulates at damage foci induced by aphidicolin and microirradiation and colocalizes with major DNA damage response proteins 53BP1 and γH2AX, revealing 5hmC as an epigenetic marker of DNA damage. Deficiency for the TET enz  ...[more]

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