Project description:TEL-JAK2 is a fusion oncogene resulting from a t(9;12) chromosomal translocation in T-ALL, translated as a constitutively activated TEL-JAK2 tyrosine kinase. Mice carrying a TEL-JAK2 transgene develop T-ALL. Gene deregulated in TEL-JAK2 T-ALL cells as compared to mouse thymocytes were identified

2013-09-28 | GSE51241 | GEO

TEL-AML1 (ETV6-RUNX1) in B-cells and leukemia (part 6)

Project description:We identified directly and indirectly regulated target genes utilizing an inducible TEL-AML1 system derived from the murine pro B-cell line BA/F3 and a monoclonal antibody directed against TEL-AML1. By integration of promoter binding identified with ChIP-on-chip, gene expression and protein output through microarray technology and stable labelling of amino acids in cell culture (SILAC), we identified directly and indirectly regulated targets of the TEL-AML1 fusion protein.

2013-11-04 | GSE50735 | GEO

TEL-AML1 (ETV6-RUNX1) in B-cells and leukemia (part 5)

2013-11-04 | GSE50734 | GEO

TEL-AML1 (ETV6-RUNX1) in B-cells and leukemia (part 4)

2013-11-04 | GSE50733 | GEO

TEL-AML1 (ETV6-RUNX1) in B-cells and leukemia (part 3)

2013-11-04 | GSE50732 | GEO

TEL-AML1 (ETV6-RUNX1) in B-cells and leukemia (part 2)

2013-11-04 | GSE50731 | GEO