Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: miRNA profiles of 50 HB tumors

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA303088 | ENA |

REPOSITORIES: ENA

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Publications


Despite being the most common liver cancer in children, hepatoblastoma (HB) is a rare neoplasm. Consequently, few pretreatment tumors have been molecularly profiled, and there are no validated prognostic or therapeutic biomarkers for HB patients. We report on the first large-scale effort to profile pretreatment HBs at diagnosis. Our analysis of 88 clinically annotated HBs revealed three risk-stratifying molecular subtypes that are characterized by differential activation of hepatic progenitor ce  ...[more]

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