Genomics,Multiomics

Dataset Information

0

Mus musculus


ABSTRACT: Single-cell transcriptomics reveals receptor transformations during olfactory neurogenesis

OTHER RELATED OMICS DATASETS IN: E-GEOD-75413

PROVIDER: PRJNA304154 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR2961020_1.fastq.gz Fastqsanger.gz
SRR2961020_2.fastq.gz Fastqsanger.gz
SRR2961030_1.fastq.gz Fastqsanger.gz
SRR2961030_2.fastq.gz Fastqsanger.gz
SRR2961040_1.fastq.gz Fastqsanger.gz
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Publications

Single-cell transcriptomics reveals receptor transformations during olfactory neurogenesis.

Hanchate Naresh K NK   Kondoh Kunio K   Lu Zhonghua Z   Kuang Donghui D   Ye Xiaolan X   Qiu Xiaojie X   Pachter Lior L   Trapnell Cole C   Buck Linda B LB  

Science (New York, N.Y.) 20151105 6265


The sense of smell allows chemicals to be perceived as diverse scents. We used single-neuron RNA sequencing to explore the developmental mechanisms that shape this ability as nasal olfactory neurons mature in mice. Most mature neurons expressed only one of the ~1000 odorant receptor genes (Olfrs) available, and at a high level. However, many immature neurons expressed low levels of multiple Olfrs. Coexpressed Olfrs localized to overlapping zones of the nasal epithelium, suggesting regional biase  ...[more]

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