Genomics

Dataset Information

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Plasmodium falciparum


ABSTRACT: Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression

ORGANISM(S): Plasmodium falciparum  

PROVIDER: PRJNA305391 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR2981460.fastq.gz Fastqsanger.gz
SRR2981461.fastq.gz Fastqsanger.gz
SRR2981459.fastq.gz Fastqsanger.gz
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Publications

Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression.

Lasonder Edwin E   Rijpma Sanna R SR   van Schaijk Ben C L BC   Hoeijmakers Wieteke A M WA   Kensche Philip R PR   Gresnigt Mark S MS   Italiaander Annet A   Vos Martijn W MW   Woestenenk Rob R   Bousema Teun T   Mair Gunnar R GR   Khan Shahid M SM   Janse Chris J CJ   Bártfai Richárd R   Sauerwein Robert W RW  

Nucleic acids research 20160613 13


Sexual differentiation of malaria parasites into gametocytes in the vertebrate host and subsequent gamete fertilization in mosquitoes is essential for the spreading of the disease. The molecular processes orchestrating these transitions are far from fully understood. Here, we report the first transcriptome analysis of male and female Plasmodium falciparum gametocytes coupled with a comprehensive proteome analysis. In male gametocytes there is an enrichment of proteins involved in the formation o  ...[more]

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