Dataset Information


Homo sapiens

ABSTRACT: EBNA3 proteins regulate EBNA2 binding to distinct RBPJ genomic sites

ORGANISM(S): Homo sapiens  



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Epstein-Barr Virus Nuclear Antigen 3 (EBNA3) Proteins Regulate EBNA2 Binding to Distinct RBPJ Genomic Sites.

Wang Anqi A   Welch Rene R   Zhao Bo B   Ta Tram T   Keleş Sündüz S   Johannsen Eric E  

Journal of Virology 20151230 6

Latent infection of B lymphocytes by Epstein-Barr virus (EBV) in vitro results in their immortalization into lymphoblastoid cell lines (LCLs); this latency program is controlled by the EBNA2 viral transcriptional activator, which targets promoters via RBPJ, a DNA binding protein in the Notch signaling pathway. Three other EBNA3 proteins (EBNA3A, EBNA3B, and EBNA3C) interact with RBPJ to regulate cell gene expression. The mechanism by which EBNAs regulate different genes via RBPJ remains unclear.  ...[more]

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