Project description:Drosophila melanogaster small RNA sequencing from dcr-2[G31R] homozygous males and from loqs[KO] homozygous males bearing a loqs[PB] transgene

| PRJNA252606 | ENA

Drosophila melanogaster

Project description:Expression data from wildtype adult Drosophila males and females

| PRJNA102697 | ENA

Drosophila melanogaster

Project description:Immunogenic males: a genome-wide analysis of reproduction and the cost of mating in Drosophila melanogaster females

| PRJNA111145 | ENA

Drosophila melanogaster

Project description:Expression profiling individual DrosDel flies heterozygous for deletions of chromosome 2L in a hybrid background

| PRJNA298537 | ENA

Transcriptional profiling of Drosophila melanogaster heads from experimentally-evolved populations

Project description:We used RNA sequencing to examine the transcriptomes of male and female heads from experimentally-evolved D. melanogaster populations after 117 generations of mating system manipulation in order to examine the pattern of evolution in sex-biased genes. Examined head transcriptomes of 3 monogamous populations and 3 polygamous populations, both males and females, for 12 total samples.

2014-03-17 | E-GEOD-50915 | biostudies-arrayexpress

Identifying the transcriptomic effects of tRNA-induced proline-to-serine mistranslation in Drosophila melanogaster

Project description:Mistranslation describes the misincorporation of an amino acid into a nascent polypeptide. Mistranslation has diverse effects on multicellular eukaryotes and is implicated in several human diseases. We introduced a mistranslating serine transfer RNA (tRNA) into Drosophila melanogaster that misincorporates serine at proline codons and found that it affected male and female flies differently. Here, we compare the transcriptomic response of male and female flies to mistranslation to identify cellular pathways that underlie this sex-specific response. Both males and females downregulated genes associated with metabolism in response to proline-to-serine mistranslation. Only males downregulated genes associated with developmental processes and response to negative stimuli such as infection, whereas only females downregulated aerobic respiration and ATP synthesis genes. Both sexes upregulated genes associated with gametogenesis but females upregulated cell cycle and DNA maintenance genes, suggesting that mistranslation may compromise genome integrity in females. This transcriptomic analysis advances our understanding of how males and females respond to mistranslation and has important implications for future studies that examine the influence of mistranslation on disease.

2024-05-11 | GSE256332 | GEO

Drosophila melanogaster

Project description:Ectopically expressed MSL2 females compared with normal females

| PRJNA177512 | ENA