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Maternal Plasma Folate impacts Differential DNA Methylation in an Epigenome-wide Meta-Analysis of Newborns

ABSTRACT: Maternal Plasma Folate impacts Differential DNA Methylation in an Epigenome-wide Meta-Analysis of Newborns

PROVIDER: PRJNA308779 | ENA |

REPOSITORIES: ENA

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Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns.

Project description: Not available

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Maternal folate and newborn DNA methylation meta-analysis

Project description:<p>Folic acid is routinely recommended for women trying to conceive to ensure proper fetal development. Mechanisms whereby periconceptional folate influences normal development and disease are poorly understood: epigenetics may be involved. This data represents meta-analysis results from a large epigenomics study to examine the association between maternal plasma folate during pregnancy and epigenome-wide DNA methylation using Illumina's HumanMethyl450 (450K) Beadchip in 1,996 newborns from two European cohorts. Results for all CpGs analyzed (419,905) are provided. </p> <p>These data may be downloaded through the dbGaP Authorized Access portal under phg000701.v1.</p>

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Project description:Genome wide DNA methylation profiling of placenta samples from 48 newborns. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. Bisulphite converted DNA from the 48 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2

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Epigenome analysis of placenta samples from newborns

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Epigenome analysis of cord blood samples from newborns

Project description:Genome wide DNA methylation profiling of cord blood samples from 48 newborns. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. Bisulphite converted DNA from the 48 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2

2012-03-28 | E-GEOD-36812 | biostudies-arrayexpress

Homo sapiens

Project description:Maternal Plasma Folate impacts Differential DNA Methylation in an Epigenome-wide Meta-Analysis of Newborns

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Epigenome analysis of cord blood samples from newborns

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Low paternal dietary folate alters the sperm epigenome and is associated with negative pregnancy outcomes

Project description:We hypothesized that the availability of folate, a soluble B vitamin, would alter the levels of DNA methylation in spermatogenesis with consequences for the sperm epigenome and pregnancy outcomes. We fed male mice with either a folate-deficient or a folate-sufficient diet throughout life. Males fed the folate-deficient diet had offspring with increased birth defects, which included craniofacial and musculoskeletal malformations. These phenotypes corresponded to developmental genes with altered methylation in sperm. To determine if there was transmission of epigenetic effects from sires to offspring, global gene expression levels were assessed in placenta from 18.5 dpc fetuses sired by either a folate-sufficient or folate-deficient male. Gene expression was measured in placenta of 18.5 dpc fetuses sired by either a folate sufficient male (n=4 placentas from different litters and different fathers) or a folate deficient (FD) male (n=4 placentas from different litters and different fathers).

2013-11-06 | E-GEOD-51819 | biostudies-arrayexpress

Low paternal dietary folate alters the sperm epigenome and is associated with negative pregnancy outcomes

2013-11-06 | GSE51819 | GEO

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