Genomics

Dataset Information

235

Homo sapiens


ABSTRACT: Targetting super enhancer associated oncogenes in esophageal squamous cell carcinoma [RNA-seq]

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA308805 | ENA |

REPOSITORIES: ENA

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Publications


Oesophageal squamous cell carcinoma (OSCC) is an aggressive malignancy and the major histological subtype of oesophageal cancer. Although recent large-scale genomic analysis has improved the description of the genetic abnormalities of OSCC, few targetable genomic lesions have been identified, and no molecular therapy is available. This study aims to identify druggable candidates in this tumour.High-throughput small-molecule inhibitor screening was performed to identify potent anti-OSCC compounds  ...[more]

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