Genomics

Dataset Information

118

Independent roles of switching and hypermutation in the development and persistence of B lymphocyte memory


ABSTRACT: Independent roles of switching and hypermutation in the development and persistence of B lymphocyte memory

PROVIDER: PRJNA308811 | ENA |

REPOSITORIES: ENA

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Publications

Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory.

Gitlin Alexander D AD   von Boehmer Lotta L   Gazumyan Anna A   Shulman Ziv Z   Oliveira Thiago Y TY   Nussenzweig Michel C MC  

Immunity 20160302 4


Somatic hypermutation (SHM) and class-switch recombination (CSR) increase the affinity and diversify the effector functions of antibodies during immune responses. Although SHM and CSR are fundamentally different, their independent roles in regulating B cell fate have been difficult to uncouple because a single enzyme, activation-induced cytidine deaminase (encoded by Aicda), initiates both reactions. Here, we used a combination of Aicda and antibody mutant alleles that separate the effects of CS  ...[more]

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