Genomics

Dataset Information

118

Homo sapiens


ABSTRACT: RUNX super-enhancer control through the Notch pathway by Epstein-Barr virus transcription factors regulates B cell growth

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA308834 | ENA |

REPOSITORIES: ENA

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Publications

RUNX super-enhancer control through the Notch pathway by Epstein-Barr virus transcription factors regulates B cell growth.

Gunnell Andrea A   Webb Helen M HM   Wood C David CD   McClellan Michael J MJ   Wichaidit Billy B   Kempkes Bettina B   Jenner Richard G RG   Osborne Cameron C   Farrell Paul J PJ   West Michelle J MJ  

Nucleic acids research 20160215 10


In B cells infected by the cancer-associated Epstein-Barr virus (EBV), RUNX3 and RUNX1 transcription is manipulated to control cell growth. The EBV-encoded EBNA2 transcription factor (TF) activates RUNX3 transcription leading to RUNX3-mediated repression of the RUNX1 promoter and the relief of RUNX1-directed growth repression. We show that EBNA2 activates RUNX3 through a specific element within a -97 kb super-enhancer in a manner dependent on the expression of the Notch DNA-binding partner RBP-J  ...[more]

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