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MicroRNA expression levels during the pseudoglandular to canalicular phase transition of fetal lung development

ABSTRACT: microRNA expression levels during the pseudoglandular to canalicular phase transition of fetal lung development

PROVIDER: PRJNA308935 | ENA |

REPOSITORIES: ENA

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microRNA expression levels during the pseudoglandular to canalicular phase transition of fetal lung development

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-02-04 | GSE76921 | GEO

Juvenility and Vegetative Phase Transition in Tropical/Subtropical Tree Crops.

Project description:In plants, juvenile to adult phase transition is regulated by the sequential activity of two microRNAs: miR156 and miR172. A decline in miR156 and increase in miR172 abundance is associated with phase transition. There is very limited information on phase transition in economically important horticultural tree crops, which have a significantly long vegetative phase affecting fruit bearing. Here we profiled various molecular cues known to be involved in phase transition and flowering, including the microRNAs miR156 and miR172, in three horticultural tree crops avocado (Persea americana), mango (Mangifera indica) and macadamia (Macadamia integrifolia). We observed that miR156 expression decreases as these trees age and can potentially be used as a juvenility marker. Consistent with findings in annual plants, we also observed conserved regulation of the miR156-SPL3/4/5 regulatory module in these genetically distant tree crops, suggesting that this pathway may play a highly conserved role in vegetative identity. Meanwhile, the abundance of miR172 and its target AP2-like genes, as well as the accumulation level of SPL9 transcripts, were not related with plant age in these crops except in avocado where miR172 expression increased steadily. Finally, we demonstrate that various floral genes, including AP1 and SOC1 were upregulated in the reproductive phase and can be used as potential markers for the reproductive phase transition. Overall, this study provides an insight into the molecular associations of juvenility and phase transition in horticultural trees where crop breeding and improvement is encumbered by long juvenile phases.

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miRNA expression in the canalicular phase of human lung development

Project description:MicroRNA expression levels were assessed during the canalicular phase of normal fetal lung development at the critical time, when the distal airway epithelium proliferates and differentiates. Precise miRNA regulation is important for proper pulmonary organogenesis, supporting the delicate balance between expansion of progenitor cells and their terminal differentiation. Microarray analyses could indicate the potential involvement of miRNAs important for human pulmonary hypoplasia. Two replicates of pooled RNA from two 18-20 week old fetal lung samples

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MicroRNA expression data in human fetal lungs

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Effect of sigH in the growth phase transition of Clostridium difficile

Project description:This study is based on two microarray datasets, in one hand a phase transition comparison using the expression profiles of 630E strain after 4h and 10h of growth. In other hand a comparison at 10h of growth between a mutant of the sigH gene and the WT strains. This experimental procedure was designed to investigate the effect of sigH in the growth phase transition of Clostridium difficile. This SuperSeries is composed of the SubSeries listed below.

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The Pseudomonas fluorescens Crc affects the length of the transition phase during diauxic growth

Project description:Pseudomonads, unlike enteric bacteria, prefer to utilize tricarboxylic acid cycle intermediates over glucose. The crc gene has been implicated to impart repression on glucose and other metabolic enzymes in various Pseudomonas species when grown in a mixture of glucose and various organic acids. The crc gene of P. fluorescens strain MB101 has been identified and a crc deletion derivative was constructed. Unlike a crc mutant of P. aeruginosa described earlier, the P. fluorescens ïcrc did not begin to catabolize glucose until most of the succinate has been utilized in a medium containing both carbon sources. The transition phase during diauxic growth in succinate/glucose media was found to be shorter in a strain lacking crc and considerably longer in a strain overproducing Crc as compared to the wild type. DNA microarray analyses were performed with wild-type and crc mutant strains during the transition phase from succinate to glucose. In the wild-type strain, high expression signals were obtained for genes normally induced in cells that approach or are in stationary phase. By contrast, ïcrc cells showed higher expression signals for genes associated with rapid growth than the wild-type strain. Taken together, this data indicates that Crc influences the length of the lag during the transition phase from succinate to glucose by directly or indirectly affecting the mRNA levels of target genes. Keywords: time course strain comparison These are time course experiments to compare crc mutant strain to the wildtype MB101 strain at 5, 6, 7, 8, and 9 ht time points. Dye swaps were included in each time point comparison. There are 10 pairs in total.

2010-06-19 | E-GEOD-5829 | biostudies-arrayexpress

Effect of sigH in the growth phase transition of Clostridium difficile

Project description:This SuperSeries is composed of the following subset Series: GSE25474: Comparison of the expression profiles of 630E strain after 4h and 10h of growth GSE25475: Comparison of the expression profiles of 630E strain and a sigH mutant after 10h of growth This study is based on two microarray datasets, in one hand a phase transition comparison using the expression profiles of 630E strain after 4h and 10h of growth. In other hand a comparison at 10h of growth between a mutant of the sigH gene and the WT strains. This experimental procedure was designed to investigate the effect of sigH in the growth phase transition of Clostridium difficile. Refer to individual Series

2011-08-21 | E-GEOD-25521 | biostudies-arrayexpress

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