Dataset Information


Xenopus laevis

ABSTRACT: Differential expression analysis of triple knockdown of TBP and TBP-related factors (TKD) in Xenopus laevis embryos at early developmental stage 10.5

ORGANISM(S): Xenopus laevis  



Dataset's files

Action DRS
SRR3107014.fastq.gz Fastqsanger.gz
SRR3107015.fastq.gz Fastqsanger.gz
SRR3107016.fastq.gz Fastqsanger.gz
SRR3107017.fastq.gz Fastqsanger.gz
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Activation of a T-box-Otx2-Gsc gene network independent of TBP and TBP-related factors.

Gazdag Emese E   Jacobi Ulrike G UG   van Kruijsbergen Ila I   Weeks Daniel L DL   Veenstra Gert Jan C GJ  

Development (Cambridge, England) 20160307 8

Embryonic development relies on activating and repressing regulatory influences that are faithfully integrated at the core promoter of individual genes. In vertebrates, the basal machinery recognizing the core promoter includes TATA-binding protein (TBP) and two TBP-related factors. In Xenopus embryos, the three TBP family factors are all essential for development and are required for expression of distinct subsets of genes. Here, we report on a non-canonical TBP family-insensitive (TFI) mechani  ...[more]

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