Dataset Information


Mus musculus

ABSTRACT: RNA-seq data from murine eGFP+ relbfl/flnfkb2fl/flCg1-Cre and Cg1-Cre splenic germinal center B cells purified by fluorescent activated cell sorting.

ORGANISM(S): Mus musculus  



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Transcription factors of the alternative NF-κB pathway are required for germinal center B-cell development.

De Silva Nilushi S NS   Anderson Michael M MM   Carette Amanda A   Silva Kathryn K   Heise Nicole N   Bhagat Govind G   Klein Ulf U  

Proceedings of the National Academy of Sciences of the United States of America 20160725 32

The NF-κB signaling cascade relays external signals essential for B-cell growth and survival. This cascade is frequently hijacked by cancers that arise from the malignant transformation of germinal center (GC) B cells, underscoring the importance of deciphering the function of NF-κB in these cells. The NF-κB signaling cascade is comprised of two branches, the canonical and alternative NF-κB pathways, mediated by distinct transcription factors. The expression and function of the transcription fac  ...[more]

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